تفاعل #2028949

معادلة التفاعل

HCl

KOH

7

(Z)-ethyl 3-(1-hydroxy-2-methylpropan-2-ylamino)-2-(2,3,4,5-tetrafluorobenzoyl)acrylate

KOH

→

9,10-Difluoro-3,3-dimethyl-7-oxo-3,7-dihydro-2H-(1,4)oxazino(2,3,4-ij)quinoline-6-carboxylic acid

المردود 83.0%

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwere added under ice-
2. 2
   درجة الحرارةcooling
3. 3
   ترشيحThe white precipitate was collected by filtration
4. 4
   أخرىto give 8, which
5. 5
   أخرىwas used without further purification in the next step (7.5 g, 83% yield)

الإجراء التجريبي

To a solution of 7 (11.2 g, 30.8 mmol) in THF (45 mL), crushed pellets of KOH (4.32 g, 77 mmol) were added under ice-cooling. After 1.5 h, 50 mL of 10% aqueous KOH were added and the reaction mixture was heated up slowly to 85° C. and stirred for another 2 hours. The reaction mixture was acidified with 1 N HCl to pH 4. The white precipitate was collected by filtration to give 8, which was used without further purification in the next step (7.5 g, 83% yield).

المصدر