تفاعل #2028947

معادلة التفاعل

5

(S)-8-amino-9,10-difluoro-3-methyl-7-oxo-3,7-dihydro-2H-(1,4)oxazino(2,3,4-ij)quinoline-6-carbonitrile

3-(pyridine-3-yl)propan-1-amine

→

title compound

المردود 15.1%

(S)-8-amino-9-fluoro-3-methyl-7-oxo-10-(3-(pyridin-3-yl)propylamino)-3,7-dihydro-2H-(1,4)oxazino(2,3,4-ij)quinoline-6-carbonitrile

المردود 15.1%

المذيبات

DMSO

ظروف التفاعل

المعالجة

1. 1
   أخرىThe DMSO was removed under vacuo
2. 2
   أخرىthe remaining solid was purified by preparative HPLC

الإجراء التجريبي

To a solution of 5 (30 mg, 0.108 mmol) in 5 ml of DMSO, 29.5 mg (0.216 mmol) of 3-(pyridine-3-yl)propan-1-amine were added. The reaction mixture was heated to 120° C. for 3 h. The DMSO was removed under vacuo and the remaining solid was purified by preparative HPLC to give the title compound as a yellow solid (6.4 mg, 15% yield).

المصدر