تفاعل #2028945

معادلة التفاعل

3

(S)-9,10-difluoro-3-methyl-8-nitro-7-oxo-3,7-dihydro-2H-(1,4)oxazino(2,3,4-ij)quinoline-6-carboxamide

sodium hydrosulfite

water

→

4

المردود 80.0%

(S)-8-amino-9,10-difluoro-3-methyl-7-oxo-3,7-dihydro-2H-(1,4)oxazino(2,3,4-ij)quinoline-6-carboxamide

المردود 80.0%

المذيبات

water methanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe suspension was refluxed for 5 h until all starting material
2. 2
   ترشيحa light yellow solid was collected by filtration
3. 3
   غسيلwashed with water
4. 4
   أخرىThe solid was dried under vacuo

الإجراء التجريبي

To a suspension of 3 (1 g, 3.07 mmol) in a mixture of water/methanol (1:1 v/v, 30 mL) was added sodium hydrosulfite (Na2S2O4, 4.3 g, 24.6 mmol). The suspension was refluxed for 5 h until all starting material has disappeared. Upon completion, the reaction mixture was cooled to room temperature and 50 mL of water were added. After 20 minutes, a light yellow solid was collected by filtration and washed with water. The solid was dried under vacuo to give 4 (725 mg, 74% yield), which was used in the next step without further purification.

المصدر