تفاعل #2028892

معادلة التفاعل

compound

4-[4-bromomethyl-5-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide

collidine

dimethyl sulfoxide

→

desired product

المردود 66.0%

4-[4-formyl-5-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide

المردود 66.0%

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction solution was partitioned between ethyl acetate and water
2. 2
   غسيلthe organic solution was washed with water
3. 3
   أخرىdried
4. 4
   تركيزconcentrated
5. 5
   أخرىThe residue was chromatographed (1:1 hexane:ethyl acetate)

الإجراء التجريبي

To a solution of the compound prepared in Step 1 (362 mg, 0.79 mmol) in dimethyl sulfoxide (7 mL) was added collidine (0.14 mL, 1.0 mmol). The solution was heated at 120° C. for 3 hours and then kept at overnight at room temperature. The reaction solution was partitioned between ethyl acetate and water and the organic solution was washed with water, dried and concentrated. The residue was chromatographed (1:1 hexane:ethyl acetate) to give the desired product (205 mg, 66%).

المصدر