تفاعل #2028884

معادلة التفاعل

HCl

sodium methoxide

Ethyl trifluoroacetate

6-methyltetralone

→

oil

المردود 85.1%

6-methyl-2-(trifluoroacetyl)tetralone

المردود 85.1%

المذيبات

ether

ظروف التفاعل

المعالجة

1. 1
   أخرىThe organic layer was collected
2. 2
   غسيلwashed with brine
3. 3
   تجفيفdried over MgSO4
4. 4
   تركيزconcentrated in vacuo

الإجراء التجريبي

Ethyl trifluoroacetate (5.33 g, 37.5 mmol) was dissolved in ether (50 mL) and treated with a sodium methoxide solution (25% in methanol, 9.92 g, 45.9 mmol) followed by 6-methyltetralone (5.94 g, 37.1 mmol). The reaction was stirred at room temperature for 6.1 hours then treated with 1N HCl (20 mL). The organic layer was collected, washed with brine, dried over MgSO4, and concentrated in vacuo to give a brown oil (8.09 g) that was used in the next step without further purification.

المصدر