تفاعل #2025290

معادلة التفاعل

sodium borohydride

ethanol

chloroform

2-(4-acetylphenyl)-5-decyloxypyrimidine

→

2-{4-(1-hydroxyethyl)phenyl}-5-decyloxypyrimidine

المردود 99.9%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwhile maintaining the temperature at 30° to 35° C.
2. 2
   استخلاصextracted with 400 ml of ethyl acetate
3. 3
   غسيلThe organic phase was washed sufficiently
4. 4
   تجفيفdried over anhydrous magnesium sulfate
5. 5
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure

الإجراء التجريبي

To a mixed solvent of 200 ml of ethanol and 100 ml of chloroform were added 35.5 g (0.1 mole) of 2-(4-acetylphenyl)-5-decyloxypyrimidine, and while maintaining the temperature at 30° to 35° C., 2.65 g (0.07 mole) of sodium borohydride were gradually added thereto. After stirring at the same temperature for 4 hours, the reaction mixture was poured into 500 ml of water and extracted with 400 ml of ethyl acetate. The organic phase was washed sufficiently, dried over anhydrous magnesium sulfate, and then the solvent was distilled off under reduced pressure to obtain 35.6 g (yield: 99.9 %) of 2-{4-(1-hydroxyethyl)phenyl}-5-decyloxypyrimidine.

المصدر