تفاعل #2025285

معادلة التفاعل

hydrochloric acid

acetic acid

4-phenyl-2-butanol

toluene

→

2-acetoxy-4-phenylbutane

المردود 98.5%

المذيبات

pyridine

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwere charged
2. 2
   أخرىto react them for 4 hours
3. 3
   درجة الحرارةwhile temperature being maintained at 40°-50° C
4. 4
   أخرىAfter completion of the reaction
5. 5
   استخلاصextracted
6. 6
   غسيلan organic layer was washed with 1N hydrochloric acid, water, 5% sodium bicarbonate solution and water in the order
7. 7
   تركيزThe thus-obtained organic layer was concentrated under a reduced pressure

الإجراء التجريبي

Into a four-necked flask provided with a thermometer and a stirrer, 150 g (1 mol) of 4-phenyl-2-butanol (XXX-35), 500 ml of toluene and 200 ml of pyridine were charged. 122.4 g (1.2 mol) of anhydrous acetic acid and 1 g of 4-dimethylaminopyridine were further added thereto to react them for 4 hours, while temperature being maintained at 40°-50° C. After completion of the reaction, the reaction mixture was poured into 500 ml of 4N hydrochloric acid solution, extracted and fractionated, and then an organic layer was washed with 1N hydrochloric acid, water, 5% sodium bicarbonate solution and water in the order. The thus-obtained organic layer was concentrated under a reduced pressure to obtain 189 g of 2-acetoxy-4-phenylbutane (XXIX-35) with yield of 98.5%.

المصدر