تفاعل #2017279

معادلة التفاعل

DCM ethyl acetate methanol

sodium borohydride

berberine hydrochloride

sodium borohydride

→

title compound

المردود 85.0%

Dihydroberberine

المردود 85.0%

المذيبات

pyridine

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGstirring
2. 2
   workup.WAITwas continued for 1 h
3. 3
   workup.ADDITIONThe mixture was poured onto ice water
4. 4
   ترشيحThe precipitate was filtered
5. 5
   غسيلthe residue washed with water
6. 6
   تجفيفdried under vacuum over calcium chloride

الإجراء التجريبي

To a solution of berberine hydrochloride (3,718 g, 10 mmol) in pyridine (30 mL) was added portionwise sodium borohydride (450 mg, 12 mmol) and the mixture was stirred at room temperature for 30 min. More sodium borohydride (380 mg, 10 mmol) was added and stirring was continued for 1 h. The reduction was monitored by TLC (DCM-ethyl acetate-methanol 4:4:2). The mixture was poured onto ice water. The precipitate was filtered, the residue washed with water and then dried under vacuum over calcium chloride to give 2.860 g of title compound in about 85 % yield.

المصدر