تفاعل #2015426

معادلة التفاعل

THF

2-(3′-nitro-biphenyl-3-yl)-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine

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title compound

المردود 85.2%

3′-[4-Trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidin-2-yl]-biphenyl-3-ylamine

المردود 85.2%

المذيبات

MeOH

ظروف التفاعل

المعالجة

1. 1
   أخرىthe catalyst was removed by filtration
2. 2
   أخرىthe obtained solution evaporated
3. 3
   أخرىThe crude product was further purified by crystallization from diethyl ether/hexane

الإجراء التجريبي

To a stirred suspension of 2-(3′-nitro-biphenyl-3-yl)-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine (1.6 g, 3.27 mmol) in MeOH (40 mL) was added at room temperature Pd—C (10%, 0.16 g) and THF (40 mL). The mixture was stirred at room temperature under H2 atmosphere for 2 h, the catalyst was removed by filtration and the obtained solution evaporated. The crude product was further purified by crystallization from diethyl ether/hexane to yield the title compound as an off-white solid (1.28 g, 85%). MS (ISP) 460.2 [(M+H)+]; mp 156.5° C.

المصدر