تفاعل #2009969

معادلة التفاعل

2-chloro-4-morpholin-4-ylthieno[3,2-d]pyrimidine-6-carbaldehyde

3,3-dimethyl-1-oxetan-3-ylpiperazine

sodium triacetoxyborohydride

→

title compound

المردود 49.0%

2-Chloro-6-(2,2-dimethyl-4-oxetan-3-ylpiperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine

المردود 49.0%

المذيبات

DCE

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGto stir for 18 h
2. 2
   ترشيحthen filtered through Celite®
3. 3
   غسيلwas washed with MeOH
4. 4
   غسيلthe product eluted with 2M NH3/MeOH
5. 5
   أخرىThe resulting residue was purified by column chromatography (Si—PCC, MeOH:EtOAc, 0-10%)

الإجراء التجريبي

A mixture of 2-chloro-4-morpholin-4-ylthieno[3,2-d]pyrimidine-6-carbaldehyde (400 mg, 1.42 mmol), 3,3-dimethyl-1-oxetan-3-ylpiperazine (290 mg, 1.71 mmol) and 4 Å powdered molecular sieves (500 mg) in DCE (20 mL) were allowed to stir at r.t. 3 h before the addition of sodium triacetoxyborohydride (420 mg, 1.98 mmol). The resulting mixture was allowed to stir for 18 h then filtered through Celite®. The filtrate was loaded onto an Isolute® SCX-2 cartridge which was washed with MeOH and the product eluted with 2M NH3/MeOH. The resulting residue was purified by column chromatography (Si—PCC, MeOH:EtOAc, 0-10%) affording the title compound as a cream solid (305 mg, 49%)._LCMS (method H): RT 2.12 min, [M+H]+ 438.3

المصدر