تفاعل #2006423

معادلة التفاعل

4-vinyl-benzoic acid

benzenethiol

VAZO

→

white solid

المردود 85.0%

4-(2-Thiophenyl)-ethyl Benzoic Acid

المردود 85.0%

المذيبات

benzene

ظروف التفاعل

المعالجة

1. 1
   أخرىAccording to the published procedure (Gareau et al., Tet. Lett., 1994, 1837), under nitrogen atmosphere in a 50 mL round bottomed flask
2. 2
   درجة الحرارةat reflux
3. 3
   أخرىthe solvent was evaporated under vacuo
4. 4
   أخرىThe solid was purified by trituration

الإجراء التجريبي

According to the published procedure (Gareau et al., Tet. Lett., 1994, 1837), under nitrogen atmosphere in a 50 mL round bottomed flask containing 4-vinyl-benzoic acid (1.0 g, 6.75 mmoles) in 10 mL of benzene (0.7 M) was added benzenethiol (797 μL, 7.76 mmoles) followed by VAZO™ (Aldrich Chemical Company, 495 mg, 2.02 mmoles). The mixture was stirred for 12 hours at reflux. The resulting solution was cooled at room temperature and the solvent was evaporated under vacuo. The solid was purified by trituration using hexane and dichloromethane to afford 1.94 g (85%) of white solid.

المصدر