تفاعل #2006417

معادلة التفاعل

4-carbomethoxybenzaldehyde

acetophenone

sodium methoxide

HCl

→

Methyl-4-(3-oxo-3-phenylpropenyl)-benzoate

المذيبات

methanol

EtOAc

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthen heated
2. 2
   درجة الحرارةto reflux for 1 hour
3. 3
   درجة الحرارةcooled down to room temperature
4. 4
   أخرىThe layers were separated
5. 5
   تجفيفthe organic layer dried over anhydrous MgSO4
6. 6
   ترشيحfiltered
7. 7
   أخرىThe solvent was evaporated under vacuum
8. 8
   أخرىto afford a yellow solid, which
9. 9
   أخرىwas recrystallized from acetonitrile/water
10. 10
    أخرىto give a pale yellow crystalline solid

الإجراء التجريبي

To 4-carbomethoxybenzaldehyde (79 mg, 0.48 mmol) and acetophenone (56 μL, 0.48 mmol) in anhydrous methanol (1.6 mL), was added neat sodium methoxide (26 mg, 0.48 mmol). The mixture was stirred at room temperature overnight then heated to reflux for 1 hour, cooled down to room temperature and added HCl 1N and EtOAc. The layers were separated and the organic layer dried over anhydrous MgSO4 and filtered. The solvent was evaporated under vacuum to afford a yellow solid, which was recrystallized from acetonitrile/water to give a pale yellow crystalline solid.

المصدر