تفاعل #2006416

معادلة التفاعل

Sodium methoxide

4-carboxybenzaldehyde

acetophenone

→

43

المردود 72.0%

4-(3-oxo-3-Phenylpropenyl)-benzoic Acid

المردود 72.0%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىhalf of the volume of methanol was removed under reduced pressure
2. 2
   workup.ADDITIONThe mixture was poured into HCl 1M (50 mL) (until pH=2) and ethyl acetate
3. 3
   workup.ADDITIONwas added
4. 4
   استخلاصThe separated aqueous layer was extracted with ethyl acetate (3×30 mL)
5. 5
   تجفيفdried (MgSO4 anh.)
6. 6
   ترشيحfiltered
7. 7
   أخرىevaporated
8. 8
   أخرىThe residue was triturated with dichloromethane-hexanes (1:1)

الإجراء التجريبي

Sodium methoxide (1.8 g, 33.3 mmol) was added to a stirred suspension of 4-carboxybenzaldehyde (2.5 g, 16.6 mmol) and acetophenone (2.0 g uL, 16.6 mmol) in methanol (50 mL) at room temperature. The mixture was stirred at room temperature for 16 hours, and half of the volume of methanol was removed under reduced pressure. The mixture was poured into HCl 1M (50 mL) (until pH=2) and ethyl acetate was added. The separated aqueous layer was extracted with ethyl acetate (3×30 mL) dried (MgSO4 anh.), filtered and evaporated. The residue was triturated with dichloromethane-hexanes (1:1) to afford 3 g of 43 (72% yield).

المصدر