تفاعل #2000134

معادلة التفاعل

Trans-2-[4-(trifluoromethyl)phenyl]vinylboronic acid

product

3,3-dimethyl-N-[3-(pyridin-3-yl)pyrazolo[1,5-a]pyrimidin-2-yl]butanamide

→

title compound

3,3-dimethyl-N-(3-{(E)-2-[4-(trifluoromethyl)phenyl]vinyl}pyrazolo[1,5-a]pyrimidin-2-yl)butanamide

ظروف التفاعل

الإجراء التجريبي

Trans-2-[4-(trifluoromethyl)phenyl]vinylboronic acid and the product from Example 110B were processed using the method analogous to that described in Example 110C to provide the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 10.27-10.28 (bs, 1H), 9.11 (dd, J=6.9, 1.7 Hz, 1H), 8.69 (dd, J=4.1, 1.7 Hz, 1H), 7.63-7.73 (m, 5H), 7.34 (d, J=16.5 Hz, 1H), 7.15 (dd, J=6.9, 4.1 Hz, 1H), 2.35 (s, 2H), 1.09 (s, 9H); MS (ESI) m/z 403 (M+H)+.

المصدر