تفاعل #1994264

معادلة التفاعل

1-naphthol

2,2,2-trifluoroethyl p-toluenesulfonate

potassium carbonate

dimethyl sulfoxide

→

target compound

المردود 78.7%

1-(2,2,2-trifluoroethoxy)naphthalene

المردود 78.7%

المذيبات

toluene

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated
2. 2
   درجة الحرارةAfter cooling
3. 3
   غسيلIt was washed 5 times with 100 g of 5 wt % sodium hydroxide aqueous solution
4. 4
   تركيزThe organic layer was concentrated
5. 5
   أخرىobtaining 36 g of oily matter
6. 6
   workup.DISTILLATIONIt was distilled in vacuum (75° C./13 Pa)

الإجراء التجريبي

In a nitrogen atmosphere, a suspension of 34 g of 1-naphthol, 40 g of 2,2,2-trifluoroethyl p-toluenesulfonate, 33 g of potassium carbonate, and 80 g of dimethyl sulfoxide was heated and stirred at 100° C. for 12 hours. After cooling, 100 g of water and 200 g of toluene were added to the suspension, after which an organic layer was taken out. It was washed 5 times with 100 g of 5 wt % sodium hydroxide aqueous solution, then 4 times with 100 g of water. The organic layer was concentrated, obtaining 36 g of oily matter. It was distilled in vacuum (75° C./13 Pa), obtaining 28 g (yield 76%) of the target compound.

المصدر