تفاعل #1994260

معادلة التفاعل

10-(biphenyl-4-yl)-2-phenyl-9,10-dihydroacridine

bromosuccinimide

→

10-(biphenyl-4-yl)-2-bromo-7-phenyl-9,10-dihydroacridine

المردود 70.0%

المذيبات

chloroform

ظروف التفاعل

المعالجة

1. 1
   غسيلthe resultant solution was washed with distilled water
2. 2
   استخلاصThen, an organic layer was extracted
3. 3
   تجفيفdried with sodium sulfate so as
4. 4
   أخرىto remove the solvent
5. 5
   أخرىThe residue was purified by silica gel column chromatography (methylene chloride/n-hexane (1/10))

الإجراء التجريبي

10-(biphenyl-4-yl)-2-phenyl-9,10-dihydroacridine (7.8 g, 19.0 mmol) was added with chloroform (300 ml), and with bromosuccinimide (3.7 g, 21.0 mmol). The resultant solution was stirred at room temperature for 2 hours. After the reaction was completed, the resultant solution was washed with distilled water. Then, an organic layer was extracted and dried with sodium sulfate so as to remove the solvent. The residue was purified by silica gel column chromatography (methylene chloride/n-hexane (1/10)) to obtain 10-(biphenyl-4-yl)-2-bromo-7-phenyl-9,10-dihydroacridine compound (pale yellow solid, 6.5 g, yield 70%).

المصدر