تفاعل #1994258

معادلة التفاعل

10-(biphenyl-4-yl)-9,10-dihydroacridine

bromosuccinimide

→

10-(biphenyl-4-yl)-2-bromo-9,10-dihydroacridine

المردود 77.7%

المذيبات

chloroform

ظروف التفاعل

المعالجة

1. 1
   غسيلthe resultant solution was washed with distilled water
2. 2
   استخلاصThen, an organic layer was extracted
3. 3
   تجفيفdried with sodium sulfate so as
4. 4
   أخرىto remove the solvent
5. 5
   أخرىThe residue was purified by silica gel column chromatography (methylene chloride/n-hexane (1/20))

الإجراء التجريبي

The obtained 10-(biphenyl-4-yl)-9,10-dihydroacridine (15.3 g, 45.9 mmol) was added with chloroform (500 ml), and then with bromosuccinimide (9.8 g, 55.1 mmol). The resultant solution was stirred at room temperature for 2 hours. After the reaction was completed, the resultant solution was washed with distilled water. Then, an organic layer was extracted and dried with sodium sulfate so as to remove the solvent. The residue was purified by silica gel column chromatography (methylene chloride/n-hexane (1/20)) to obtain 10-(biphenyl-4-yl)-2-bromo-9,10-dihydroacridine compound (white solid, 14.7 g, yield 77%).

المصدر