تفاعل #1994248

معادلة التفاعل

8-nitro-2-naphthylquinoline

sodium borohydride

HCl

→

crystalline solid

المردود 135.5%

8-Amino-2-naphthylquinoline

المردود 135.5%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGAfter stirring for 2 h
2. 2
   أخرىThe solvent is then removed
3. 3
   غسيلthe resultant residue is washed vigorously with water
4. 4
   أخرىrecrystallised from dioxane
5. 5
   ترشيحThe precipitate is filtered
6. 6
   أخرىdried in vacuo

الإجراء التجريبي

12.6 g (42 mmol) of 8-nitro-2-naphthylquinoline and 1.99 g of Pd/C (10%) are suspended in 200 ml of methanol. 8.4 g (222 mmol) of sodium borohydride are added in portions with stirring at 0° C. After stirring for 2 h, the clear solution is neutralised using dilute HCl. The solvent is then removed, and the resultant residue is washed vigorously with water and recrystallised from dioxane. The precipitate is filtered and dried in vacuo, giving 9.9 g (56.9 mmol) of crystalline solid. The overall yield is 88%.

المصدر