تفاعل #1994233

معادلة التفاعل

tramadol HCl

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Tramadol

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONslowly adding 1,345 g of AMBERLITE™
2. 2
   workup.ADDITIONThe dispersion was mixed for 4 hours and upon completion
3. 3
   أخرىbefore decanting the supernatant
4. 4
   أخرىThe wet resin complex was then dried in a VWR™ convection oven
5. 5
   workup.ADDITIONKOLLICOAT™ SR-30D polymer (467 g) was then slowly added to the wet resin complex in a Hobart type mixer (Kitchen Aid)
6. 6
   أخرىto form a uniform mass
7. 7
   أخرىThe wet mass was again dried in a 50° C
8. 8
   أخرىThe semi-dried granules were then milled through a 40 mesh screen
9. 9
   أخرىcontinued drying under 50° C. until the moisture content
10. 10
    أخرىThe dried granules were then milled through a 40 mesh screen

الإجراء التجريبي

The Tramadol Resin Complex was prepared by first dissolving 500 g of tramadol HCl in 8 liters of purified water, and then slowly adding 1,345 g of AMBERLITE™ IRP-69 resin with continuous mixing. The dispersion was mixed for 4 hours and upon completion, allowed to settle before decanting the supernatant. The slurring/decanting process was repeated twice with sufficient amounts of purified water. The wet resin complex was then dried in a VWR™ convection oven maintained at 50° C. until moisture content was about 25%. KOLLICOAT™ SR-30D polymer (467 g) was then slowly added to the wet resin complex in a Hobart type mixer (Kitchen Aid) to form a uniform mass. The wet mass was again dried in a 50° C. VWR™ convection oven to the moisture content around 20%. The semi-dried granules were then milled through a 40 mesh screen using CO-MIL™ brand mill and continued drying under 50° C. until the moisture content was between 4-6%. The dried granules were then milled through a 40 mesh screen using CO-MIL™ brand mill.

المصدر