تفاعل #1985941

معادلة التفاعل

bromine

4-acetoxy-3-methoxybenzaldehyde

sodium acetate

iodine

→

desired product

4-Acetoxy-6-bromo-3-methoxybenzaldehyde

المذيبات

water

acetic acid

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGstirred at room temperature for 3 days
2. 2
   ترشيحfiltered
3. 3
   workup.DISSOLUTIONThe solid is dissolved in toluene
4. 4
   غسيلthe solution washed with brine
5. 5
   تجفيفdried over magnesium sulfate
6. 6
   ترشيحfiltered
7. 7
   تركيزconcentrated in vacuo
8. 8
   أخرىThe residue is recrystallized twice from hexanes

الإجراء التجريبي

To a mixture of 4-acetoxy-3-methoxybenzaldehyde (75.7 g), anhydrous sodium acetate (76 g) and iodine (0.8 g) in acetic acid (300 ml) is added bromine (21 ml). The mixture is warmed to 45° C. for about 1 hour, then stirred stirred at room temperature for 3 days, poured into water (700 ml) and filtered. The solid is dissolved in toluene and the solution washed with brine, dried over magnesium sulfate, filtered and concentrated in vacuo. The residue is recrystallized twice from hexanes to give the desired product.

المصدر