تفاعل #1985937

معادلة التفاعل

ammonium hydroxide

bis-[5-(2-methoxycarbonylethyl)-3-[5-(2-methoxycarbonylethyl)-2-hydroxybenzyl]2-hydroxyphenyl]methane

sodium hydroxide

→

desired product

Bis-[5-(2-carboxyethyl)-3-[5-(2-carboxyethyl)-2-hydroxybenzyl]2-hydroxyphenyl]methane

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىThe mixture is quenched with dilute aqueous hydrochloric acid (HCl)
2. 2
   أخرىThe mixture is quenched as above and the organic soluble material flash
3. 3
   أخرىchromatographed
4. 4
   غسيلeluting with 10% methanol in chloroform
5. 5
   أخرىThe product so obtained

الإجراء التجريبي

A solution of bis-[5-(2-methoxycarbonylethyl)-3-[5-(2-methoxycarbonylethyl)-2-hydroxybenzyl]2-hydroxyphenyl]methane (0.10 g) in methanol (2 ml) is stirred with 10% aqueous sodium hydroxide (NaOH) (1 ml) at room temperature. The mixture is quenched with dilute aqueous hydrochloric acid (HCl) and the organic soluble material retreated as above. The mixture is quenched as above and the organic soluble material flash chromatographed, eluting with 10% methanol in chloroform. The product so obtained is treated with ammonium hydroxide solution and lyophilized to give the desired product as the ammonium salt, m.p. 150° C. (dec.).

المصدر