تفاعل #1985

معادلة التفاعل

compound

1-benzyl-3-trifluoromethylpyrrolidine-3-carboxylic acid

LAH

→

title compound

المردود 99.9%

1-benzyl-3-trifluoromethylpyrrolidine-3-methanol

المردود 99.9%

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction was quenched by the sequential dropwise addition of 0.35 mL water, 0.35 mL of 15% NaOH and 1.3 mL of water
2. 2
   workup.STIRRINGthe mixture was stirred for 1 hour
3. 3
   ترشيحfiltered
4. 4
   أخرىThe filtrate was dried
5. 5
   تركيزconcentrated

الإجراء التجريبي

The compound from step 456a (2.32 g) was dissolved in 60 mL of dry THF, 1.12 eq of LAH (1N in dry THF) was added, and the reaction was stirred under N2 for 3 hours. The reaction was quenched by the sequential dropwise addition of 0.35 mL water, 0.35 mL of 15% NaOH and 1.3 mL of water, then the mixture was stirred for 1 hour and filtered. The filtrate was dried and concentrated to give 2.2 g of the title compound.

المصدر