تفاعل #1982
ord-7b48bd4f78a1409eb2c2a20f041bf0c4
معادلة التفاعل
2-(trifluoromethyl)acrylic acid
N-benzyl-N-(methoxymethyl)-trimethylsilylmethylamine
trifluoroacetic acid
→
title product
1-benzyl-3-trifluoromethylpyrrolidine-3-carboxylic acid
المتفاعلات
الكواشف
لا شيء
ظروف التفاعل
الظروف التفصيلية
See reaction.notes.procedure_details.
المعالجة
- 1أخرىThe product was removed by filtration
- 2غسيلwashed
- 3أخرىdried
الإجراء التجريبي
A 2.48 g sample of 2-(trifluoromethyl)acrylic acid was dissolved in 40 mL of dry methylene chloride, and a solution of 4.75 g of N-benzyl-N-(methoxymethyl)-trimethylsilylmethylamine in 20 mL of dry methylene chloride was added dropwise under N2 at 0° C. To this mixture was added 2 mL of trifluoroacetic acid, and the mixture was stirred for 2 hours at room temperature. The product was removed by filtration, washed and dried to give the title product.