تفاعل #1976447

معادلة التفاعل

2-methyl-2-{[1-(2-phenoxy-ethoxy)-naphthalene-2-carbonyl]-amino}-butyric acid methyl ester

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2-Methyl-2-{[1-(2-phenoxy-ethoxy)-naphthalene-2-carbonyl]-amino}-butyric acid

المذيبات

THF

sodium hydroxide

methanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةunder reflux for 3 h
2. 2
   أخرىThe organic solvents were then removed in vacuo
3. 3
   استخلاصextracted with ethyl acetate twice
4. 4
   تجفيفThe combined organic layers were dried over magnesium sulphate
5. 5
   تركيزconcentrated
6. 6
   أخرىAfter recrystallization from toluene 240 mg of 2-methyl-2-{[1-(2-phenoxy-ethoxy)-naphthalene-2-carbonyl]-amino}-butyric acid
7. 7
   أخرىwere obtained

الإجراء التجريبي

419 mg 2-methyl-2-{[1-(2-phenoxy-ethoxy)-naphthalene-2-carbonyl]-amino}-butyric acid methyl ester in 25 ml THF, 1.5 ml of 2 M sodium hydroxide and 8 ml methanol were heated under reflux for 3 h. The organic solvents were then removed in vacuo, and the residue was acidified with 2 M hydrochloric acid and extracted with ethyl acetate twice. The combined organic layers were dried over magnesium sulphate, and concentrated. After recrystallization from toluene 240 mg of 2-methyl-2-{[1-(2-phenoxy-ethoxy)-naphthalene-2-carbonyl]-amino}-butyric acid were obtained.

المصدر