تفاعل #1973737

معادلة التفاعل

2-methyl-6-isopropylaniline

tetrafluoboric acid

sodium nitrite

→

2-fluoro-3-isopropyltoluene

المردود 61.0%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe precipitated diazonium tetrafluoborate is filtered off under suction
2. 2
   workup.ADDITIONThe suspension is added dropwise to a flask
3. 3
   أخرىpreheated at 150° C
4. 4
   أخرىthe product is obtained by distillation over a Claisen still (bath temperature 100° C., pressure 4 mbar, distillation temperature 41°-42° C.)

الإجراء التجريبي

44.7 g (0.3 mole) of 2-methyl-6-isopropylaniline are added dropwise to 200 ml of 40% strength tetrafluoboric acid at 5° C., followed by a solution of 20.7 g of sodium nitrite in 20 ml of water. The mixture is stirred for 1 hour at 10° C. The precipitated diazonium tetrafluoborate is filtered off under suction and suspended in succession in 50 ml of ice water, 50 ml of cold ethanol and 50 ml of diethyl ether. The suspension is added dropwise to a flask preheated at 150° C. When the evolution of gas has ended, the product is obtained by distillation over a Claisen still (bath temperature 100° C., pressure 4 mbar, distillation temperature 41°-42° C.). 28 g (61%) of 2-fluoro-3-isopropyltoluene are obtained.

المصدر