تفاعل #1969502

معادلة التفاعل

[2-(4-Nitrophenoxy)-ethoxy]acetic acid methyl ester

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75

المردود 71.1%

[2-(4-Amino-phenoxy)-ethoxy]-acetic acid methyl ester

المردود 71.1%

المذيبات

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   أخرىfor 30 minutes
2. 2
   ترشيحThe catalyst was filtered
3. 3
   تركيزthe filtrate concentrate hexane (3 mL)
4. 4
   workup.ADDITIONadded
5. 5
   ترشيحfiltered solid

الإجراء التجريبي

[2-(4-Nitrophenoxy)-ethoxy]acetic acid methyl ester 74 (1 grams, 3.9 mmol) was dissolved in anhydrous ethyl acetate (20 mL), palladium carbon (10%, 0.1 gram) added and the mixture stirred under an atmosphere of H using balloon for 30 minutes. The catalyst was filtered, the filtrate concentrate hexane (3 mL) added, filtered solid to give 75 (625 mg, 70.9%) as a light brown powder. The melting point was found to be 51-52.5° C. The structure was confirmed with IR and NMR. IHNMR (CDCl3) 3.04 (bs, 2H, NH2), 3.72 (s, 3H, ester), 3.88 (t, 2H, OCH2), 4.08 (t, 2H, OCH2), 4.20 (s, 2H, OCH2), 6.58 (d, 2H, Ar), 6.70 (d, 2H, Ar).

المصدر