تفاعل #1955

معادلة التفاعل

water

4-chloro-5-fluoro-2-picoline

product

4-Chloro-5-fluoro-2-picoline

t-butylhypochlorite

→

title compound

3,4-Dichloro-5-fluoro-2-picoline

المذيبات

chloroform

ظروف التفاعل

المعالجة

1. 1
   استخلاصthe resultant aqueous mixture is extracted with methylene chloride
2. 2
   تجفيفThe organic solution is dried over anhydrous magnesium sulfate
3. 3
   ترشيحfiltered
4. 4
   تركيزconcentrated under reduced pressure
5. 5
   workup.DISTILLATIONdistilled

الإجراء التجريبي

To 0.87 g (6 mmol) of 4-chloro-5-fluoro-2-picoline, the product of Example 66, in 20 mL of chloroform cooled to -45° C., is added 0.75 mL of t-butylhypochlorite. The reaction mixture is stirred at -45° C. for 2 hours and at 0° C. for 2 hours. The reaction mixture is then poured into water and the resultant aqueous mixture is extracted with methylene chloride. The organic solution is dried over anhydrous magnesium sulfate, filtered, concentrated under reduced pressure and distilled to afford the title compound.

المصدر