تفاعل #1946559

معادلة التفاعل

chloroacetic acid

N,N-di-n-butyl-N′-(4-t-butylbenzoyl)thiourea

compound 1-2

N,N-di-n-butyl-N′-(4-t-butylbenzoyl)thiourea

sodium hydroxide

→

product

المردود 49.7%

2-Dibutylamino-4-(4-t-butylphenyl)thiazole

المردود 49.7%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةheated on a steam bath for 22 hrs
2. 2
   درجة الحرارةcooled
3. 3
   أخرىThe water phase was decanted from the solid phase
4. 4
   غسيلthe solid was washed with water and methanol
5. 5
   أخرىRecrystallization of the solid from methanol

الإجراء التجريبي

To a mixture of 174.15 g (0.50 mol) of N,N-di-n-butyl-N′-(4-t-butylbenzoyl)thiourea (compound 1-2), 44.0 g (1.10 mol) of sodium hydroxide and 500 ml of water was added 56.70 g (0.60 mol) of chloroacetic acid. The mixture was stirred and heated on a steam bath for 22 hrs and cooled. The water phase was decanted from the solid phase, and the solid was washed with water and methanol. Recrystallization of the solid from methanol gave 85.6 g (49.7% yield) of product; mp: 48.5-49.5° C. The NMR spectrum was consistent with the proposed structure. Anal. Calcd. for C21H32N2S: C, 73.20; H, 9.36; N, 8.13; S, 9.30. Found: C, 73.04; H, 9.29; N, 8.02; S, 9.19.

المصدر