تفاعل #1929062

معادلة التفاعل

HCl

potassium hydrogen carbonate

6-(chloracetamido) hexanoic acid

potassium cyanide

→

6-(cyanacetamido)hexanoic acid

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas cooled on ice
2. 2
   استخلاصThe residue after extraction
3. 3
   أخرىwas purified by chromatography (silica gel, solvent: ethyl acetate)

الإجراء التجريبي

2.8 g (20 mMol) potassium hydrogen carbonate was added to 8.3 g (40 mMol) 6-(chloracetamido) hexanoic acid dissolved in 25 ml water. 3.2 g (48 mMol) potassium cyanide was then added to the clear solution which was cooled on ice. The reaction mixture was stirred for 17 hours and was then acidified with HCl (2 N). The residue after extraction was purified by chromatography (silica gel, solvent: ethyl acetate).

المصدر