تفاعل #1929013

معادلة التفاعل

triethyltrifluorovinylsilane

1-chloro-4-propylcyclohexane

4,4′-di-tert-butylbiphenyl

lithium

→

[(Z)-1,2-difluoro-2-(4-propylcyclohexyl)vinyl]triethylsilane

المذيبات

Water

THF

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONare added at 0° C
2. 2
   درجة الحرارةThe mixture is warmed slowly
3. 3
   استخلاصthe batch is extracted with MTBE
4. 4
   استخلاصThe aqueous phase is extracted with MTBE
5. 5
   غسيلthe combined organic phases are washed with water and saturated sodium chloride solution
6. 6
   أخرىThe solution is dried
7. 7
   تركيزconcentrated under reduced pressure
8. 8
   ترشيحis filtered off
9. 9
   تركيزThe filtrate is concentrated under reduced pressure
10. 10
    أخرىthe residue is purified by column chromatography (SiO2, pentane)

الإجراء التجريبي

74.1 g (0.28 mol) of 4,4′-di-tert-butylbiphenyl are initially introduced in 1000 ml of THF in an argon atmosphere, and 1.6 g (0.23 mol) of lithium (granules) are added at 0° C. After 5 h, the blue solution is cooled to −78° C., and 40.6 g (0.25 mol) of 1-chloro-4-propylcyclohexane are added. After 30 min at this temperature, 49.6 g (0.25 mol) of triethyltrifluorovinylsilane are metered in. The mixture is warmed slowly and stirred at room temperature for 16 h. Water is added, and the batch is extracted with MTBE. The aqueous phase is extracted with MTBE, and the combined organic phases are washed with water and saturated sodium chloride solution. The solution is dried using sodium sulfate and concentrated under reduced pressure. The residue is digested with methanol, and insoluble material is filtered off. The filtrate is concentrated under reduced pressure, and the residue is purified by column chromatography (SiO2, pentane), giving [(Z)-1,2-difluoro-2-(4-propylcyclohexyl)vinyl]triethylsilane as a colourless oil.

المصدر