تفاعل #1929004

معادلة التفاعل

compound ( 48 )

4-bromo-1-[5-(trifluoromethyl)-2-pyridyl]piperidine

sodium hydride

DMF

compound ( 46 )

2-propoxy-4-(trifluoromethyl)benzenethiol

→

4-[2-propoxy-4-(trifluoromethyl)phenylsulfanyl]-1-[5-(trifluoromethyl)-2-pyridyl]piperidine

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated to 100° C.
2. 2
   workup.STIRRINGwas then stirred for 1 hour
3. 3
   درجة الحرارةAfter the mixture was cooled
4. 4
   استخلاصwas then subjected to extraction with ethyl acetate
5. 5
   غسيلAfter its organic layer was washed with water
6. 6
   تجفيفwas then dried with anhydrous magnesium sulfate, it
7. 7
   ترشيحwas filtered
8. 8
   تركيزwas then concentrated under reduced pressure
9. 9
   أخرىIts residue was purified by column chromatography
10. 10
    أخرىto produce the chemical compound

الإجراء التجريبي

After 60% sodium hydride was added, with chilling on ice, to the DMF (7 ml) solution of the chemical compound (46) (0.62 g), it was warmed to room temperature, and was then stirred for 30 minutes. After the chemical compound (48) (0.74 g) was added to the mixture, it was heated to 100° C., and was then stirred for 1 hour. After the mixture was cooled, it was poured into water, and was then subjected to extraction with ethyl acetate. After its organic layer was washed with water, and was then dried with anhydrous magnesium sulfate, it was filtered, and was then concentrated under reduced pressure. Its residue was purified by column chromatography to produce the chemical compound mentioned in the above title (0.90 g).

المصدر