تفاعل #1929003

معادلة التفاعل

Sodium borohydride

( 28 )

N-benzyl-3-azabicyclo[3.3.1]nonane-9-one

→

crude compound ( 29 )

المردود 191.5%

N-benzyl-3-azabicyclo[3.3.1]nonane-9-ol

المردود 191.5%

N-benzyl-3-azabicyclo[3.3.1]nonane-9-one

المذيبات

MeOH

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwith chilling on ice
2. 2
   درجة الحرارةwith chilling on ice, its solvent
3. 3
   أخرىwas evaporated under reduced pressure
4. 4
   workup.ADDITIONWater was added to its residue, which
5. 5
   استخلاصwas then subjected to extraction with methylene chloride
6. 6
   تجفيفby drying its organic layer with anhydrous magnesium sulfate
7. 7
   أخرىIts solvent was evaporated under reduced pressure

الإجراء التجريبي

N-benzyl-3-azabicyclo[3.3.1]nonane-9-one (28) was synthesized according to a method described in J. Med. Chem. 1994, 37, 2831-2840. Sodium borohydride (1.49 g) was added into the MeOH (80 ml) solution of (28) (6.75 g) with chilling on ice. After its mixture was stirred for 1 hour with chilling on ice, its solvent was evaporated under reduced pressure. Water was added to its residue, which was then subjected to extraction with methylene chloride, followed by drying its organic layer with anhydrous magnesium sulfate. Its solvent was evaporated under reduced pressure to produce a crude compound (29) (6.52 g).

المصدر