تفاعل #1927

معادلة التفاعل

methyl 3-bromomethyl-2-thiophenecarboxylate

triphenylphosphine

→

2-methoxycarbonylthiophen-3-ylmethyltriphenylphosphonium bromide

المردود 70.4%

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe precipitated crystals were collected by filtration
2. 2
   أخرىdried

الإجراء التجريبي

To a solution of methyl 3-bromomethyl-2-thiophenecarboxylate (7.31 g, 31.1 mmol) in toluene (90 ml) was added triphenylphosphine (7.92 g, 30.2 mmol) under ice cooling. The temperature of the mixture was raised to room temperature, followed by stirring for 2 days. The precipitated crystals were collected by filtration and dried to give 2-methoxycarbonylthiophen-3-ylmethyltriphenylphosphonium bromide (10.57 g, 70.4%). This product was subjected to the reaction of Reference Example 13 without purification.

المصدر