تفاعل #1925198

معادلة التفاعل

hydrochloric acid

5-[4-(3-methyl-3-hydroxybutyne-1-yl)phenoxy]pentanol

toluene

sodium hydroxide

→

5-(4-ethynylphenoxy)pentanol

المردود 98.1%

المذيبات

ethyl acetate

water

ظروف التفاعل

المعالجة

1. 1
   أخرىA flask equipped with a stirrer
2. 2
   درجة الحرارةunder reflux for 4 hours
3. 3
   workup.ADDITIONwere added to the reactant
4. 4
   استخلاصto an acidity and effect ethyl acetate extraction
5. 5
   غسيلThe resulting organic phase was washed with NaCl saturated water
6. 6
   تجفيفdried over anhydrous sodium sulfate
7. 7
   ترشيحfiltered
8. 8
   تركيزconcentrated

الإجراء التجريبي

A flask equipped with a stirrer and a thermometer was charged with 5.41 g (20.6 mmol) of 5-[4-(3-methyl-3-hydroxybutyne-1-yl)phenoxy]pentanol and 70 ml of toluene under a nitrogen atmosphere. To the flask, 1.65 g (41.2 mmol) of sodium hydroxide was added, and stirred under reflux for 4 hours. After the completion of the reaction, water, 1N hydrochloric acid, and ethyl acetate were added to the reactant to adjust the pH to an acidity and effect ethyl acetate extraction. The resulting organic phase was washed with NaCl saturated water, dried over anhydrous sodium sulfate, filtered, and concentrated to thereby obtain 4.13 g of 5-(4-ethynylphenoxy)pentanol in the form of a brown oil in a 98% yield.

المصدر