تفاعل #1918644

معادلة التفاعل

5-Phenylmethylthio-7-chloro-thiazolo[4,5-d]pyrimidin-2-ylamin

DL-2-amino-1-hexanol

potassium carbonate

→

title compound

المردود 17.6%

(±)-2-(2-Amino-5-phenylmethylthio-thiazolo[4,5-d]pyrimidin-7-ylamino)-hexan-1-ol

المردود 17.6%

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe solution was filtered
2. 2
   أخرىthe solvent was evaporated
3. 3
   أخرىchromatographed on silica (gradient eluent—ammonia:ethylacetate:dichloromethane, 1:69:30 to 1:99:0)

الإجراء التجريبي

5-Phenylmethylthio-7-chloro-thiazolo[4,5-d]pyrimidin-2-ylamin (100 mg, 0.32 mmol), DL-2-amino-1-hexanol (295 μL, 2.3 mmol) and potassium carbonate (124 mg, 0.90 mmol) were heated for 24 hours as in Example 1. The solution was filtered and the solvent was evaporated. The crude product was flash chromatographed on silica (gradient eluent—ammonia:ethylacetate:dichloromethane, 1:69:30 to 1:99:0) resulting in 22 mg (17% yield) of the title compound as a yellow solid.

المصدر