تفاعل #1916

معادلة التفاعل

4-Phenyl semicarbazide

3-hydroxy-2-pyridine carbaldehyde

→

product

المردود 99.0%

3-Hydroxy-2-[[(N-phenylaminocarbonyl)hydrazono]methyl] pyridine

المردود 99.0%

المذيبات

ethanol water

ظروف التفاعل

المعالجة

1. 1
   ترشيحthe yellow product was collected by filtration
2. 2
   غسيلThe yellow precipitate was washed with EtOH/H2O 1:1
3. 3
   أخرىdried under P2 O5

الإجراء التجريبي

4-Phenyl semicarbazide (4.91 g, 33 mmol) was added to a suspension of 3-hydroxy-2-pyridine carbaldehyde (4.0 g, 33 mmol) in a mixture of ethanol water (30 mL:40 mL). The reaction mixture was stirred at room temperature for 3 h and the yellow product was collected by filtration. The yellow precipitate was washed with EtOH/H2O 1:1 and dried under P2 O5 to yield 8.22 g (99%) of product. It can be recrystallized from EtOH/H2O; m.p. 201°-2° C. (dec.). 1H NMR (d6 -DMSO) d: 10.85 (br.s., 1H); 10.6 (br.s., 1H); 9.14 (s, 1H); 8.27 (s, 1H); 8.15 (d 9f d, 1H); 7.55 (d, 2H); 7.26-7.36 (m, 4H); 7.01 (t, 1H).

المصدر