تفاعل #1909787

معادلة التفاعل

3,4-dichloro-2,4-dihydroxybenzoic acid

L-phenylalanine methyl ester hydrochloride

WSC.HCl

HOBT

→

title compound

المردود 63.1%

N-(3,5-Dichloro-2,4-dihydroxybenzoyl)-L-phenylalanine methyl ester

المردود 63.1%

المذيبات

DMF

triethylamine

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONThen, the mixture was post-treated in the same manner as in the above Example 1, (Step 5)

الإجراء التجريبي

To a solution of 3,4-dichloro-2,4-dihydroxybenzoic acid (17 g), L-phenylalanine methyl ester hydrochloride (19.8 g), WSC.HCl (17.6 g) and HOBT (12.4 g) in DMF (70 ml) was added dropwise triethylamine (12.8 ml) at room temperature, and the mixture was stirred for 16 hours. Then, the mixture was post-treated in the same manner as in the above Example 1, (Step 5) to give the title compound (18.32 g, yield 57%).

المصدر