تفاعل #1909783

معادلة التفاعل

1-tert-butoxycarbonyl-4-ethylisonipecotic acid ethyl ester

lithium hydroxide

→

title compound

المردود 45.3%

1-tert-Butoxycarbonyl-4-ethylisonipecotic acid

المردود 45.3%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe mixture was refluxed
2. 2
   درجة الحرارةunder heating for 20 hours
3. 3
   تركيزThen, the reaction mixture was concentrated
4. 4
   workup.ADDITIONwater was added to the residue
5. 5
   غسيلThe aqueous layer was washed with ether
6. 6
   استخلاصextracted with ether
7. 7
   تجفيفThe organic layer was dried over anhydrous magnesium sulfate
8. 8
   تركيزconcentrated under reduced pressure

الإجراء التجريبي

To a solution of 1-tert-butoxycarbonyl-4-ethylisonipecotic acid ethyl ester (570 mg) in ethanol (10 ml) was added a 1M lithium hydroxide solution (8 ml), and the mixture was refluxed under heating for 20 hours. Then, the reaction mixture was concentrated, and water was added to the residue. The aqueous layer was washed with ether acidified with 1N hydrochloric acid, and extracted with ether. The organic layer was dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give the title compound (233 mg, yield 45%).

المصدر