تفاعل #1908970

معادلة التفاعل

3-bromo-5-phenyl-2-amino pyrazine

triethylamine

→

solid

المردود 75.0%

2-amino-5-phenylpyrazine

المردود 75.0%

المذيبات

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe reaction was filtered
2. 2
   تركيزconcentrated under reduced pressure
3. 3
   أخرىThe product was purified
4. 4
   غسيلeluting with ethyl acetate

الإجراء التجريبي

To a stirred solution of 3-bromo-5-phenyl-2-amino pyrazine (80 mg; 0.32 mmol), in ethyl acetate (1 mL) was added triethylamine (139 μL; 1.0 mmol) and Pd(OH)2 (10 mg; 20% wt on carbon). The reaction was placed under a hydrogen atmosphere at 45 psi and shook for 6 hours. The reaction was filtered and concentrated under reduced pressure. The product was purified using a biotage 12L eluting with ethyl acetate to yield an off white solid (75% yield).

المصدر