تفاعل #1904038

معادلة التفاعل

aspartic acid

triethyl amine

succinyl chloride

→

Aspartic Acid Succinimide

المذيبات

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   أخرىfitted with a condenser and nitrogen inlet
2. 2
   درجة الحرارةrefluxed for 6 hours
3. 3
   ترشيحThe triethyl amine hydrochloride is filtered
4. 4
   تركيزthe filtrate is concentrated
5. 5
   أخرىby removing the solvent under vacuum
6. 6
   أخرىThe residue is used directly for the subsequent reaction
7. 7
   أخرىThe residue can be purified by chromatography on silica gel

الإجراء التجريبي

This example that demonstrates how this method could be performed. 9.4 g aspartic acid, 10 ml triethyl amine and 100 ml tetrahydrofuran are transferred into a 100 ml flask fitted with a condenser and nitrogen inlet. The mixture is cooled to 0° C. and 5 g succinyl chloride is added and the mixture stirred under nitrogen atmosphere for 5 min and refluxed for 6 hours. The triethyl amine hydrochloride is filtered and the filtrate is concentrated by removing the solvent under vacuum. The residue is used directly for the subsequent reaction. The residue can be purified by chromatography on silica gel.

المصدر