تفاعل #1903

معادلة التفاعل

4-bromo-3-methoxyphenol

benzyl bromide

potassium carbonate

→

4-benzyloxy-2-methoxybromobenzene

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   أخرىThe insoluble materials were removed by filtration
2. 2
   تركيزthe filtrate was concentrated in vacuo
3. 3
   أخرىThe residue was purified by silica gel column chromatography (hexane:ethyl acetate=20:1)

الإجراء التجريبي

A mixture of 4-bromo-3-methoxyphenol (21 g), benzyl bromide (13.5 ml), potassium carbonate (21.4 g) and acetone (200 ml) was stirred at room temperature for 24 h. The insoluble materials were removed by filtration and the filtrate was concentrated in vacuo. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=20:1) to give 4-benzyloxy-2-methoxybromobenzene (25 g) as an oil.

المصدر