تفاعل #1893

معادلة التفاعل

2-amino-5-chloro-2'-methoxybenzophenone

sodium bicarbonate

→

2-amino-5-chloro-2'-hydroxybenzophenone

المردود 93.4%

المذيبات

hydrogen bromide

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated for 1 hour
2. 2
   درجة الحرارةunder reflux
3. 3
   استخلاصsubjected to extraction with 100 ml of ethyl acetate
4. 4
   غسيلThe extract solution was washed with water
5. 5
   تجفيفdried over anhydrous magnesium sulfate
6. 6
   workup.DISTILLATIONthe solvent was then distilled off under reduced pressure
7. 7
   أخرىThe residue was purified by means of silica gel column chromatography (eluent, hexane:ethyl acetate=10:1)

الإجراء التجريبي

A mixture of 2.15 g of 2-amino-5-chloro-2'-methoxybenzophenone and 20 ml of 47% hydrogen bromide was heated for 1 hour under reflux. The solution was rendered neutral with sodium bicarbonate, and subjected to extraction with 100 ml of ethyl acetate. The extract solution was washed with water and dried over anhydrous magnesium sulfate; the solvent was then distilled off under reduced pressure. The residue was purified by means of silica gel column chromatography (eluent, hexane:ethyl acetate=10:1) to yield 1.9 g of 2-amino-5-chloro-2'-hydroxybenzophenone as needles, m.p. 51° to 52° C.

المصدر