تفاعل #1889

معادلة التفاعل

2-amino-5-chloro-α-(2-chlorophenyl)benzyl alcohol

trifluoroacetic acid

sodium hydrogen carbonate

→

crystal

المردود 95.7%

5-chloro-α-(2-chlorophenyl)-2-(trifluoroacetylamino)benzyl alcohol

المردود 95.7%

المذيبات

dichloromethane

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter reaction
2. 2
   أخرىthe organic layer was dried
3. 3
   أخرىafter which the solvent was removed
4. 4
   أخرىthe residue was recrystallized from hexane

الإجراء التجريبي

To a solution of 1.0 g of 2-amino-5-chloro-α-(2-chlorophenyl)benzyl alcohol in 12 ml of dichloromethane, a solution of 0.8 g of anhydrous trifluoroacetic acid in 2 ml of dichloromethane was added. After reaction, an aqueous solution of sodium hydrogen carbonate was added, and the organic layer was dried, after which the solvent was removed and the residue was recrystallized from hexane to yield 1.3 g of a crystal.

المصدر