تفاعل #1888

معادلة التفاعل

trans-7-chloro-5-(2-chlorophenyl)-1-isobutyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetic acid

ammonium chloride

1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride

triethylamine

→

crystal

المردود 75.2%

Trans-7-chloro-5-(2-chlorophenyl)-1-isobutyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetamide

المردود 75.2%

المذيبات

dimethylformamide

water

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwere added
2. 2
   استخلاصthe solution was extracted with ethyl acetate
3. 3
   غسيلby washing with water
4. 4
   أخرىafter which the solvent was removed
5. 5
   أخرىthe residue was recrystallized

الإجراء التجريبي

1.0 g of trans-7-chloro-5-(2-chlorophenyl)-1-isobutyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetic acid and 0.5 g of ammonium chloride were dissolved in 8 mi of dimethylformamide, and 0.46 g of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride and 0.7 ml of triethylamine were added, followed by stirring at room temperature for 30 minutes. After water was added, the solution was extracted with ethyl acetate, followed by washing with water, after which the solvent was removed and the residue was recrystallized to yield 0.75 g of a crystal.

المصدر