تفاعل #1886

معادلة التفاعل

water

2-amino-5-chloro-2',4',6'-trimethoxybenzophenone

lithium aluminum hydride

→

crystal

المردود 96.1%

2-amino-5-chloro-α-(2,4,6-trimethoxyphenyl)benzyl alcohol

المردود 96.1%

المذيبات

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   استخلاصthe solution was extracted with ethyl acetate
2. 2
   تجفيفdried over anhydrous sodium sulfate
3. 3
   أخرىafter which the solvent was removed

الإجراء التجريبي

To a solution of 3.0 g of 2-amino-5-chloro-2',4',6'-trimethoxybenzophenone in 50 ml of tetrahydrofuran, 0.43 g of lithium aluminum hydride was added, followed by stirring for 1 hour. After water was added, the solution was extracted with ethyl acetate and dried over anhydrous sodium sulfate, after which the solvent was removed and the residue was subjected to silica gel column chromatography to yield 2.9 g of a crystal.

المصدر