تفاعل #1885062

معادلة التفاعل

Fmoc-Dap-Z

diethylamine

→

Dap-Z

المذيبات

CH2Cl2

ظروف التفاعل

المعالجة

1. 1
   تركيزthe mixture is concentrated (bath temp. <30° C.)
2. 2
   تركيزconcentrated
3. 3
   workup.ADDITIONTo the residue is added MeOH (20 mL) and CH2Cl2 (300 mL)
4. 4
   تركيزthe solution is concentrated
5. 5
   تركيزtoluene (400 mL), concentrated
6. 6
   workup.WAITthe residue left under vacuum overnight
7. 7
   أخرىto give product

الإجراء التجريبي

A 1-L round bottom flask is charged with Fmoc-Dap-Z, CH2Cl2 (122 mL) and diethylamine (61 mL, Acros). The solution is stirred at room temperature and the completion monitored by HPLC. After 7 hours, the mixture is concentrated (bath temp. <30° C.). The residue is suspended in CH2Cl2 (300 mL) and concentrated. This is repeated twice. To the residue is added MeOH (20 mL) and CH2Cl2 (300 mL), and the solution is concentrated. The residue is suspended in CH2Cl2 (100 mL) and toluene (400 mL), concentrated, and the residue left under vacuum overnight to give product.

المصدر