تفاعل #1876812

معادلة التفاعل

Bromine

Compound ( b )

3-ethoxybenzotrifluoride

Water

→

Compound ( c )

المردود 76.9%

2-bromo-5-ethoxybenzotrifluoride

المردود 76.9%

المذيبات

ether

ظروف التفاعل

المعالجة

1. 1
   استخلاصthe aqueous layer was extracted three times with ether
2. 2
   غسيلwashed with saturated aqueous sodium bicarbonate and water
3. 3
   تجفيفdried over anhydrous magnesium sulfate
4. 4
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure

الإجراء التجريبي

Bromine (18.2 g) was slowly added dropwise to Compound (b) (19.3 g) at room temperature, and then the mixture was stirred at room temperature for 1 hour. Water and ether were added for liquid separation, and the aqueous layer was extracted three times with ether. The organic layers were combined, washed with saturated aqueous sodium bicarbonate and water, and then dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain 21.0 g of Compound (c).

المصدر