تفاعل #1876811

معادلة التفاعل

Potassium carbonate

methyl ethyl ketone

ethyl iodide

MEK

3-trifluoromethylphenol

→

Compound ( b )

3-ethoxybenzotrifluoride

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe reaction mixture was heated
2. 2
   أخرىto room temperature
3. 3
   استخلاصthe aqueous layer was extracted three times with diethyl ether
4. 4
   غسيلwashed with an 1 M aqueous sodium hydroxide solution
5. 5
   تجفيفdried over anhydrous magnesium sulfate
6. 6
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure

الإجراء التجريبي

Potassium carbonate (22.6 g) and then a mixture of methyl ethyl ketone (MEK) (150 mL) and ethyl iodide (47.8 g) were added to a mixture of MEK (310 mL) and 3-trifluoromethylphenol (a) (25.0 g) at room temperature, and the reaction mixture was heated and stirred for 2 hours. After returning the mixture to room temperature, water was added for liquid separation and the aqueous layer was extracted three times with diethyl ether. The organic layers were combined, washed with an 1 M aqueous sodium hydroxide solution and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain 19.3 g of Compound (b).

المصدر