تفاعل #1869160

معادلة التفاعل

1-methyl-4-piperidone

sodium methoxide

N-[1H-indol-5-yl]naphthalene-1-sulphonamide

→

N-[3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-5-yl]naphthalene-1-sulphonamide

المردود 52.0%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe resulting solution is heated
2. 2
   درجة الحرارةto reflux for 48 hours
3. 3
   تركيزThe reaction mixture is concentrated at reduced pressure
4. 4
   أخرىthe residue obtained
5. 5
   أخرىis purified by chromatography over silica gel

الإجراء التجريبي

To a solution of 712 mg (13.2 mMol) of sodium methoxide in 100 ml of methanol are added 850 mg (2.64 mMol) of N-[1H-indol-5-yl]naphthalene-1-sulphonamide followed by 596 mg (5.28 mMol) of 1-methyl-4-piperidone and the resulting solution is heated to reflux for 48 hours. The reaction mixture is concentrated at reduced pressure and the residue obtained is purified by chromatography over silica gel, using as eluent mixtures of methylene chloride/methanol/ammonia, to yield 573 mg (52%) of N-[3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-5-yl]naphthalene-1-sulphonamide as a solid with m.p.=244-245° C.

المصدر