تفاعل #1857588

معادلة التفاعل

water

1-bromo-3-fluoro-2-vinylbenzene

n-butyllithium

water

N,N-dimethylformamide

→

3-fluoro-2-vinylbenzaldehyde

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwarmed to room temperature
2. 2
   استخلاصextracted with ethyl acetate
3. 3
   تجفيفThe combined organic phases were dried over sodium sulphate
4. 4
   تركيزconcentrated
5. 5
   أخرىPurification by column chromatography

الإجراء التجريبي

To a solution of 1-bromo-3-fluoro-2-vinylbenzene (900 mg) in THF (40 ml) was added dropwise, at −78° C., n-butyllithium (3.4 ml 1.6 M/hexane). After 60 minutes, N,N-dimethylformamide (0.69 ml) was added dropwise at −78° C. After stirring at −78° C. for 60 minutes, the reaction mixture was admixed with water and then warmed to room temperature. Then the mixture was admixed with water and extracted with ethyl acetate. The combined organic phases were dried over sodium sulphate and concentrated. Purification by column chromatography gives 3-fluoro-2-vinylbenzaldehyde (160 mg).

المصدر